1980–81 St. John's Redmen basketball team

The 1980–81 St. John's Redmen basketball team represented St. John's University during the 1980–81 NCAA Division I men's basketball season. The team was coached by Lou Carnesecca in his thirteenth year at the school. St. John's home games are played at Alumni Hall and Madison Square Garden and the team is a member of the Big East Conference.

Schedule and results
!colspan=9 style="background:#FF0000; color:#FFFFFF;"| Regular season

!colspan=9 style="background:#FF0000; color:#FFFFFF;"| Big East tournament

!colspan=9 style="background:#FF0000; color:#FFFFFF;"| NIT tournament