1980–81 Wyoming Cowboys basketball team

The 1980–81 Wyoming Cowboys basketball team represented the University of Wyoming as a member of the Western Athletic Conference during the 1980–81 NCAA Division I men's basketball season. The Cowboys, led by second-year head coach Jim Brandenburg, played their home games at War Memorial Fieldhouse in Laramie, Wyoming.

Schedule and results
!colspan=9 style=| Regular Season

!colspan=9 style=| NCAA tournament