1980 Eastern League season

The 1980 Eastern League season began on approximately April 1 and the regular season ended on approximately September 1.

The Holyoke Millers defeated the Waterbury Reds two games to one to win the Eastern League Championship Series.

Standings
Notes:
 * Green shade indicates that team advanced to the playoffs
 * Bold indicates that team advanced to ELCS
 * Italics indicates that team won ELCS

Semi-finals Series
Holyoke Millers defeated Buffalo Bisons 2 games to 0.

Waterbury Reds defeated Reading Phillies 2 games to 0.

Championship Series
Holyoke Millers defeated Waterbury Reds 2 games to 1.