1980 Holy Cross Crusaders football team

The 1980 Holy Cross Crusaders football team was an American football team that represented the College of the Holy Cross as an independent during the 1980 NCAA Division I-A football season. Neil Wheelwright returned for his fifth year as head coach. The team compiled a record of 3–8.

All home games were played at Fitton Field on the Holy Cross campus in Worcester, Massachusetts.

Statistical leaders
Statistical leaders for the 1980 Crusaders included:
 * Rushing: Mark Covington, 516 yards and 4 touchdowns on 152 attempts
 * Passing: Dave Boisture, 1,659 yards, 113 completions and 6 touchdowns on 262 attempts
 * Receiving: Brian Kelley, 639 yards and 2 touchdowns on 48 receptions
 * Scoring: Matt Michaud, 26 points from 14 PATs and 4 field goals
 * Total offense: Dave Boisture, 1,610 yards (1,659 passing, minus-49 rushing)
 * All-purpose yards: John Ahern, 813 yards (566 receiving, 198 returning, 49 rushing)
 * Interceptions: Peter George, Eric Oden and Rob Porter, 2 interceptions each (yardage: George, 23; Oden, 15; Porter, 6)
 * Tackles: Jim Cobb, 127 total tackles (62 solo, 65 assist)