1980 Jacksonville State Gamecocks football team

The 1980 Jacksonville State Gamecocks football team represented Jacksonville State University as a member of the Gulf South Conference (GSC) during the 1980 NCAA Division II football season. Led by fourth-year head coach Jim Fuller, the Gamecocks compiled an overall record of 8–3 with a mark of 6–1 in conference play, and finished second in the GSC. In the playoffs, Jacksonville State were defeated by Cal Poly in the first round.