1980 NCAA Division II basketball tournament

The 1980 NCAA Division II basketball tournament involved 32 schools playing in a single-elimination tournament to determine the national champion of men's NCAA Division II college basketball as a culmination of the 1979–80 NCAA Division II men's basketball season. It was won by Virginia Union University and Virginia Union's Keith Valentine was the Most Outstanding Player.

Regional participants
* denotes tie

South Atlantic - Catonsville, Maryland
Location: UMBC Fieldhouse Host: University of Maryland, Baltimore County


 * Third Place - Mount St. Mary's 84, Benedict 82

New England - Smithfield, Rhode Island
Location: Bryant Gymnasium Host: Bryant College


 * Third Place - Quinnipiac 102, Bryant 97

North Central - Brookings, South Dakota
Location: Frost Arena Host: South Dakota State University


 * Third Place - Stonehill 70, North Dakota 57

South - Lakeland, Florida
Location: Jenkins Fieldhouse Host: Florida Southern College


 * Third Place - West Georgia 75, Bethune-Cookman 63

West - Tacoma, Washington
Location: Memorial Fieldhouse Host: University of Puget Sound


 * Third Place - Puget Sound 93, San Francisco State 86

South Central - Warrensburg, Missouri
Location: CMSU Fieldhouse Host: Central Missouri State University


 * Third Place - Central Missouri State 112, Jacksonville State 91

East - Erie, Pennsylvania
Location: Hammermill Center Host: Gannon University


 * Third Place - Cheyney 87, Gannon 86

Great Lakes - Dayton, Ohio
Location: Physical Education Building Host: Wright State University


 * Third Place - Wright State 88, Indiana State–Evansville 85

* denotes each overtime played

National Finals - Springfield, Massachusetts
Location: Springfield Civic Center Hosts: American International College and Springfield College


 * Third Place - Florida Southern 68, North Alabama 67

* denotes each overtime played

All-tournament team

 * Johnny Buckman (North Alabama)
 * John Ebeling (Florida Southern)
 * Larry Holmes (Virginia Union)
 * Bobby Jones (New York Tech)
 * Keith Valentine (Virginia Union)