1980 Player's Canadian Open – Men's singles

Björn Borg was the defending champion, but retired in the final against Ivan Lendl due to a knee injury.

Seeds

 * 1) 🇸🇪 Björn Borg (final, retired because of a knee injury)
 * 2) 🇺🇸 John McEnroe (second round, retired because of a twisted ankle)
 * 3) 🇺🇸 Vitas Gerulaitis (third round)
 * 4)  Ivan Lendl (champion)
 * 5) 🇺🇸 John Sadri (quarterfinals)
 * 6)  Heinz Günthardt (third round)
 * 7) 🇲🇽 Raúl Ramírez (first round)
 * 8) 🇺🇸 Brian Teacher (quarterfinals)
 * 9) 🇺🇸 Tim Gullikson (third round)
 * 10) N/A
 * 11)  Andrew Pattison (second round)
 * 12) 🇺🇸 Peter Rennert (third round)
 * 13) 🇺🇸 Butch Walts (third round)
 * 14) N/A
 * 15) 🇺🇸 Bruce Manson (first round)