1980 U.S. Clay Court Championships – Men's singles

Eighth-seed José Luis Clerc claimed the title and first prize money of $28,000 by defeating qualifier Mel Purcell in the final.

Seeds
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.


 * 1) 🇺🇸 Gene Mayer (third round)
 * 2) 🇺🇸 Harold Solomon (third round)
 * 3) 🇺🇸 Eddie Dibbs (quarterfinals)
 * 4)  Ivan Lendl (second round)
 * 5) 🇪🇸 José Higueras (semifinals)
 * 6) 🇵🇱 Wojciech Fibak (quarterfinals)
 * 7)  Hans Gildemeister (first round)
 * 8) 🇦🇷 José Luis Clerc (champion)
 * 9) 🇺🇸 Victor Amaya (second round)
 * 10) 🇺🇸 Eliot Teltscher (quarterfinals)
 * 11) 🇲🇽 Raúl Ramírez (first round)
 * 12) 🇦🇺 Phil Dent (second round)
 * 13) 🇦🇺 Kim Warwick (third round)
 * 14) 🇺🇸 Hank Pfister (second round)
 * 15) 🇦🇺 Colin Dibley (first round)
 * 16) 🇺🇸 Terry Moor (quarterfinals)