1980 U.S. Clay Court Championships – Women's singles

Top-seed Chris Evert-Lloyd won the title for the sixth time, beating fourth-seed Andrea Jaeger in the final for a first-prize of $30,000.

Seeds
The eight seeds received a bye into the second round. A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.


 * 1) 🇺🇸 Chris Evert-Lloyd (champion)
 * 2) 🇦🇺 Evonne Cawley (semifinals)
 * 3) 🇷🇴 Virginia Ruzici (third round)
 * 4) 🇺🇸 Andrea Jaeger (final)
 * 5)  Regina Maršíková (quarterfinals)
 * 6) 🇦🇷 Ivanna Madruga (semifinals)
 * 7)  Mima Jaušovec (withdrew — arm injury)
 * 8) 🇺🇸 Laura duPont (second round)