1981 Campionati Internazionali di Sicilia – Singles

Guillermo Vilas was the defending champion, but did not compete this year.

Manuel Orantes won the title by defeating Pedro Rebolledo 6–4, 6–0, 6–0 in the final.

Seeds
• # Víctor Pecci (first round)

• # 🇵🇱 Wojtek Fibak (quarterfinals)

• # 🇮🇹 Adriano Panatta (first round, retired)

• # 🇪🇸 José Higueras (semifinals)

• # José Luis Damiani (second round)

• # 🇦🇷 Ricardo Cano (first round)

• # 🇧🇴 Mario Martínez (quarterfinals)

• # 🇮🇹 Corrado Barazzutti (semifinals)