1981 Eastern League season

The 1981 Eastern League season began on approximately April 1 and the regular season ended on approximately September 1.

The Bristol Red Sox defeated the Glens Falls White Sox three games to two to win the Eastern League Championship Series.

Standings
Notes:
 * Green shade indicates that team advanced to the playoffs
 * Bold indicates that team advanced to ELCS
 * Italics indicates that team won ELCS

Semi-finals Series
Bristol Red Sox defeated Reading Phillies 2 games to 0.

Championship Series
Bristol Red Sox defeated Glens Falls White Sox 3 games to 2.