1981 Grambling State Tigers football team

The 1981 Grambling State Tigers football team represented Grambling State University as a member of the Southwestern Athletic Conference (SWAC) during the 1981 NCAA Division I-AA football season. Led by 39th-year head coach Eddie Robinson, the Tigers compiled an overall record of 6–4–1 and a mark of 4–1–1 in conference play, and finished second in the SWAC.