1981 Jacksonville State Gamecocks football team

The 1981 Jacksonville State Gamecocks football team represented Jacksonville State University as a member of the Gulf South Conference (GSC) during the 1981 NCAA Division II football season. Led by fifth-year head coach Jim Fuller, the Gamecocks compiled an overall record of 8–3 with a mark of 6–0 in conference play, and finished as GSC champion. In the playoffs, Jacksonville State were defeated by Southwest Texas State in the first round.