1981 Mississippi Valley State Delta Devils football team

The 1981 Mississippi Valley State Delta Devils football team represented Mississippi Valley State University as a member of the Southwestern Athletic Conference (SWAC) during the 1981 NCAA Division I-AA football season. Led by second-year head coach Archie Cooley, the Delta Devils compiled an overall record of 4–6–1, with a conference record of 2–4, and finished tied for fifth in the SWAC.