1981 NCAA Division II baseball tournament

The 1981 NCAA Division II baseball tournament was the postseason tournament hosted by the NCAA to determine the national champion of baseball among its Division II colleges and universities at the end of the 1981 NCAA Division II baseball season. For the second consecutive year, the final tournament was played at the Riverside Sports Complex in Riverside, California.

Florida Southern defeated Eastern Illinois, 9–0, in the championship game of the double-elimination tournament, capturing the Moccasins' fifth national title and first since 1978. Florida Southern was coached by Joe Arnold.