1981 NCAA Division I baseball tournament

The 1981 NCAA Division I baseball tournament was played at the end of the 1981 NCAA Division I baseball season to determine the national champion of college baseball. The tournament concluded with eight teams competing in the College World Series, a double-elimination tournament in its thirty fifth year. Eight regional competitions were held to determine the participants in the final event. Seven regions held a four team, double-elimination tournament while one region included six teams, resulting in 34 teams participating in the tournament at the conclusion of their regular season, and in some cases, after a conference tournament. The thirty-fifth tournament's champion was Arizona State coached by Jim Brock. The Most Outstanding Player was Stan Holmes of Arizona State.

Regionals
The opening rounds of the tournament were played across eight regional sites across the country, seven consisting of four teams and one of six teams. The winners of each Regional advanced to the College World Series.

Bold indicates winner.

All-Tournament Team
The following players were members of the All-Tournament Team.

Notable players

 * Arizona State: Alvin Davis, Donnie Hill, Lemmie Miller, Billy DeMann, Kevin Romine
 * Maine: Kevin Buckley, Joe Johnson, Bill Swift
 * Miami (FL): Neal Heaton, Mike Pagliarulo
 * Michigan: Steve Ontiveros, Jim Paciorek, Chris Sabo
 * Mississippi State:
 * Oklahoma State: Gary Green, Mickey Tettleton, Jim Traber, Robbie Wine
 * South Carolina: Don Gordon
 * Texas: Mike Brumley, Spike Owen, Calvin Schiraldi, Mike Hamer