1981 US Open – Mixed doubles

Wendy Turnbull and Marty Riessen were the defending champions but lost in the first round to Wendy White and Mike Bauer.

Anne Smith and Kevin Curren won in the final 6–4, 7–6(7–4) against JoAnne Russell and Steve Denton.

Seeds
Champion seeds are indicated in bold text while text in italics indicates the round in which those seeds were eliminated.

• # Betty Stöve / Frew McMillan (second round)

• # 🇦🇺 Wendy Turnbull / 🇺🇸 Marty Riessen (first round)

• # 🇺🇸 Anne Smith / Kevin Curren (champions)

• # 🇺🇸 JoAnne Russell / 🇺🇸 Steve Denton (final)

• # Virginia Ruzici /  Ilie Năstase (quarterfinals)

• # 🇺🇸 Pam Teeguarden / Heinz Günthardt (quarterfinals)

• # 🇺🇸 Mary Lou Piatek / 🇦🇺 Ross Case (quarterfinals)

• # Bettina Bunge / 🇺🇸 Dick Stockton (semifinals)