1988 Cincinnati Open – Men's singles

Stefan Edberg was the defending champion, but lost to Mats Wilander in the final 6–3, 6–7(5–7), 6–7(5–7).

Seeds
The top eight seeds received a bye to the second round. • # 🇸🇪 Stefan Edberg (final)

• # 🇸🇪 Mats Wilander (champion)

• # 🇺🇸 Jimmy Connors (third round, withdrew because of tendinitis in his left elbow)

• # 🇦🇺 Pat Cash (second round)

• # Miloslav Mečíř (first round)

• # 🇺🇸 Brad Gilbert (third round)

• # 🇦🇷 Guillermo Pérez Roldán (first round)

• # 🇸🇪 Jonas Svensson (first round)

• # 🇪🇨 Andrés Gómez (third round, defaulted)

• # Andrei Chesnokov (second round)

• # 🇸🇪 Anders Järryd (semifinals)

• # 🇺🇸 Aaron Krickstein (semifinals)

• # Jakob Hlasek (quarterfinals)

• # 🇺🇸 Kevin Curren (quarterfinals)

• # 🇺🇸 Dan Goldie (third round)

• # 🇦🇺 Darren Cahill (first round)