1988 U.S. Men's Clay Court Championships – Singles

Seeds
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.

• # 🇺🇸 Andre Agassi (champion)

• # 🇺🇸 Aaron Krickstein (quarterfinals)

• # 🇺🇸 David Pate (first round)

• # 🇺🇸 Jay Berger (quarterfinals, retired)

• # 🇺🇸 Johan Kriek (second round)

• # 🇧🇷 Luiz Mattar (first round)

• # 🇺🇸 Jimmy Arias (final)

• # 🇳🇿 Kelly Evernden (first round)