1988 US Open – Mixed doubles

Martina Navratilova and Emilio Sánchez were the defending champions but did not compete that year.

Jana Novotná and Jim Pugh won in the final 7–5, 6–3 against Elizabeth Smylie and Patrick McEnroe.

Seeds
Champion seeds are indicated in bold text while text in italics indicates the round in which those seeds were eliminated.

• # 🇺🇸 Lori McNeil / 🇲🇽 Jorge Lozano (first round)

• # Jana Novotná / 🇺🇸 Jim Pugh (champions)

• # 🇦🇺 Elizabeth Smylie / 🇺🇸 Patrick McEnroe (final)

• # 🇺🇸 Patty Fendick / 🇺🇸 Rick Leach (second round)

• # 🇫🇷 Catherine Suire / 🇦🇺 Mark Woodforde (first round)

• # 🇺🇸 Betsy Nagelsen / 🇺🇸 Paul Annacone (second round)

• # 🇺🇸 Robin White / 🇺🇸 Kelly Jones (first round)

• # 🇺🇸 Zina Garrison / 🇺🇸 Sherwood Stewart (quarterfinals)