1990 US Open – Mixed doubles

Robin White and Shelby Cannon were the defending champions but lost in the second round to Zina Garrison and Rick Leach.

Elizabeth Smylie and Todd Woodbridge won in the final 6–4, 6–2 against Natasha Zvereva and Jim Pugh.

Seeds
Champion seeds are indicated in bold text while text in italics indicates the round in which those seeds were eliminated.

• # Natasha Zvereva / 🇺🇸 Jim Pugh (final)

• # 🇺🇸 Zina Garrison / 🇺🇸 Rick Leach (quarterfinals)

• # Elna Reinach /  Pieter Aldrich (quarterfinals)

• # 🇦🇺 Nicole Provis / Danie Visser (first round)

• # 🇪🇸 Arantxa Sánchez Vicario / 🇲🇽 Jorge Lozano (quarterfinals)

• # 🇺🇸 Betsy Nagelsen / 🇺🇸 Scott Davis (withdrew)

• # 🇺🇸 Patty Fendick / 🇺🇸 Ken Flach (first round)

• # 🇦🇺 Elizabeth Smylie / 🇦🇺 Todd Woodbridge (champions)