1991–92 UC Sampdoria season

The 1991–92 season saw Sampdoria compete in this season's editions of the Serie A, Coppa Italia, and European Cup. The club reached the 1992 European Cup Final only to suffer a 1–0 loss in extra time to Barcelona.

In the league, Sampdoria finished tied for sixth with Parma. Due to Sampdoria's failure to secure European football, championship-winning coach Vujadin Boškov left his job.