1991 US Open – Women's singles

Monica Seles defeated Martina Navratilova in the final, 7–6(7–1), 6–1 to win the women's singles tennis title at the 1991 US Open. It was her third major title of the year. With the win, Seles recaptured the world No. 1 ranking from Steffi Graf, and would hold it until her 1993 stabbing.

Gabriela Sabatini was the defending champion, but lost in the quarterfinals to Jennifer Capriati.

This marked the first major in which 1998 champion and future world No. 1 Lindsay Davenport competed in the main draw; she lost in the first round to Debbie Graham.

Seeds
• # 🇩🇪 Steffi Graf (semifinals)

• # Monica Seles (champion)

• # 🇦🇷 Gabriela Sabatini (quarterfinals)

• # 🇪🇸 Arantxa Sánchez Vicario (quarterfinals)

• # 🇺🇸 Mary Joe Fernández (third round)

• # 🇺🇸 Martina Navratilova (final)

• # 🇺🇸 Jennifer Capriati (semifinals)

• # 🇪🇸 Conchita Martínez (quarterfinals)

• # Jana Novotná (fourth round)

• # Manuela Maleeva (fourth round)

• # 🇧🇬 Katerina Maleeva (third round)

• # 🇺🇸 Zina Garrison (fourth round)

• # Leila Meskhi (third round)

• # 🇫🇷 Nathalie Tauziat (first round)

• # Helena Suková (third round)

• # 🇩🇪 Anke Huber (second round)