1992 Italian Open – Women's singles

Defending champion Gabriela Sabatini defeated Monica Seles in a rematch of the previous year's final, 7–5, 6–4 to win the women's singles tennis title at the 1992 Italian Open.

Seeds
The first eight seeds received a bye to the second round. • # Monica Seles (final)

• # 🇦🇷 Gabriela Sabatini (champion)

• # 🇺🇸 Jennifer Capriati (third round)

• # 🇺🇸 Mary Joe Fernández (semifinals)

• # 🇩🇪 Anke Huber (quarterfinals)

• # 🇧🇬 Katerina Maleeva (second round)

• # 🇫🇷 Nathalie Tauziat (quarterfinals)

• # 🇫🇷 Mary Pierce (second round)

• # Helena Suková (second round)

• # Leila Meskhi (quarterfinals)

• # 🇵🇪 Laura Gildemeister (first round)

• # Radka Zrubáková (third round)

• # Brenda Schultz (second round)

• # Natasha Zvereva (quarterfinals)

• # 🇩🇪 Barbara Rittner (first round)

• # Amanda Coetzer (semifinals)