1992 Lyon Grand Prix – Singles

The 1992 Grand Prix de Tennis de Lyon – Singles was an event of the 1992 Grand Prix de Tennis de Lyon men's tennis tournament that was played at the Palais des Sports de Gerland in Lyon, France from 14 October until 21 October 1992. The draw comprised 32 players and eight were seeded. First-seeded Pete Sampras was the defending champion and regained his singles title, defeating unseeded Cédric Pioline, in the final, 6–4, 6–2.

Seeds
• # 🇺🇸 Pete Sampras (champion)

• # 🇫🇷 Guy Forget (second round)

• # 🇺🇸 MaliVai Washington (semifinals)

• # 🇦🇹 Thomas Muster (second round)

• # Karel Nováček (quarterfinals)

• # 🇩🇪 Carl-Uwe Steeb (second round)

• # 🇮🇹 Omar Camporese (second round)

• # 🇦🇺 Wally Masur (second round)