1999 Lipton Championships – Women's singles

Defending champion Venus Williams defeated her sister Serena in the final, 6–1, 4–6, 6–4 to win the women's singles tennis title at the 1999 Miami Open.

Seeds
All seeds received a bye to the second round. • # Martina Hingis (semifinals)

• # 🇺🇸 Lindsay Davenport (quarterfinals, withdrew)

• # 🇺🇸 Monica Seles (fourth round)

• # 🇨🇿 Jana Novotná (quarterfinals)

• # 🇪🇸 Arantxa Sánchez Vicario (second round)

• # 🇺🇸 Venus Williams (champion)

• # 🇩🇪 Steffi Graf (semifinals)

• # 🇫🇷 Mary Pierce (fourth round)

• # Amanda Coetzer (quarterfinals)

• # 🇫🇷 Nathalie Tauziat (third round)

• # 🇫🇷 Sandrine Testud (second round)

• # Patty Schnyder (fourth round)

• # 🇷🇺 Anna Kournikova (fourth round)

• # 🇫🇷 Amélie Mauresmo (third round)

• # Irina Spîrlea (second round)

• # 🇺🇸 Serena Williams (final)

• # 🇧🇪 Dominique Van Roost (second round)

• # 🇪🇸 Conchita Martínez (third round)

• # 🇧🇾 Natasha Zvereva (fourth round)

• # 🇦🇹 Barbara Schett (quarterfinals)

• # 🇫🇷 Julie Halard-Decugis (third round)

• # 🇮🇹 Silvia Farina (third round)

• # 🇷🇺 Elena Likhovtseva (fourth round)

• # 🇺🇸 Chanda Rubin (third round)

• # 🇪🇸 Magüi Serna (third round)

• # 🇸🇰 Henrieta Nagyová (third round)

• # 🇩🇪 Anke Huber (fourth round)

• # 🇪🇸 Virginia Ruano Pascual (third round)

• # Cara Black (second round)

• # Iva Majoli (second round)

• # 🇫🇷 Nathalie Dechy (third round)

• # 🇺🇸 Amy Frazier (third round)

Seeds
• # 🇸🇪 Åsa Carlsson (first round)

• # Christína Papadáki (qualifying competition, lucky loser)

• # Seda Noorlander (first round)

• # Amanda Hopmans (first round)

• # Kristie Boogert (first round)

• # Emmanuelle Gagliardi (first round)

• # 🇦🇷 Mariana Díaz Oliva (first round)

• # 🇧🇬 Pavlina Stoyanova (first round)

• # 🇮🇹 Adriana Serra Zanetti (qualifier)

• # Janet Lee (qualifier)

• # 🇩🇪 Marlene Weingärtner (qualifier)

• # 🇦🇺 Alicia Molik (qualifier)

• # 🇨🇿 Sandra Kleinová (qualifier)

• # 🇺🇸 Jolene Watanabe (qualifying competition)

• # 🇮🇹 Tathiana Garbin (qualifying competition)

• # 🇺🇸 Alexandra Stevenson (first round)

Qualifiers
• # 🇮🇹 Adriana Serra Zanetti

• # 🇩🇪 Marlene Weingärtner

• # 🇨🇿 Sandra Kleinová

• # 🇩🇪 Jana Kandarr

• # 🇦🇺 Alicia Molik

• # 🇺🇸 Meilen Tu

• # Janet Lee

• # Tina Pisnik

Lucky losers

 * 1)  Christína Papadáki