1999 Mexican League season

The 1999 Mexican League season was the 75th season in the history of the Mexican League. It was contested by sixteen teams divided into three zones: North, Central and South. The season ended on 4 September with the last game of the Serie del Rey. Diablos Rojos del México won its twelfth championship after defeating Tigres Capitalinos in the Serie del Rey 4 games to 2, led by manager Tim Johnson.

No-hitters

 * Narciso Elvira (Campeche): Elvira threw two no-hitters during the season, the sixth and seventh in franchise history. The first on 20 March defeating Langosteros de Cancún 5–0 in nine innings and the second on 10 June defeating Tecolotes de los Dos Laredos 1–0 in seven innings.