1999 Mississippi Valley State Delta Devils football team

The 1999 Mississippi Valley State Delta Devils football team represented Mississippi Valley State University as a member of the Southwestern Athletic Conference (SWAC) during the 1999 NCAA Division I-AA football season. Led by first-year head coach LaTraia Jones, the Delta Devils compiled an overall record of 3–8, with a conference record of 1–3, and finished tied for third in the SWAC East Division.