1999 SEAT Open Luxembourg – Singles

The 1999 SEAT Open Luxembourg singles was the singles event of the ninth edition of the most prestigious women's tennis tournament held in Luxembourg. Mary Pierce was the defending champion but she did not compete in this year.

Qualifier Kim Clijsters won in the final, 6–2, 6–2, against top playing seed Dominique Van Roost, to win her first WTA title.

Seeds
• # 🇺🇸 Serena Williams (withdrew due to exhaustion)

• # 🇧🇪 Dominique Van Roost (final)

• # 🇨🇿 Jana Novotná (first round)

• # 🇷🇴 Irina Spîrlea (first round)

• # 🇩🇪 Anke Huber (second round)

• # 🇮🇹 Silvia Farina Elia (quarterfinals)

• # 🇦🇹 Sylvia Plischke (first round)

• # 🇱🇺 Anne Kremer (first round)

Seeds
• # 🇨🇿 Adriana Gerši (second round)

• # Miriam Oremans (first round)

• # n.a.

• # 🇧🇪 Kim Clijsters (qualifier)

• # 🇧🇪 Els Callens (qualifying competition, lucky loser)

• # Tina Pisnik (qualifier)

• # Jelena Kostanić (qualifier)

• # n.a.

• # Tina Križan (second round)

• # 🇷🇴 Raluca Sandu (first round)

Qualifiers
• # 🇧🇬 Magdalena Maleeva

• # 🇧🇪 Kim Clijsters

• # Jelena Kostanić

• # Tina Pisnik