1999 Southwest Missouri State Bears football team

The 1999 Southwest Missouri State Bears football team represented Southwest Missouri State University (now known as Missouri State University) as a member of the Gateway Football Conference (GFC) during the 1999 NCAA Division I-AA football season. Led by first-year head coach Randy Ball, the Bears compiled an overall record of 5–6, with a mark of 2–4 in conference play, and finished tied for fourth in the GFC.