1999 Torneo Internazionali Femminili di Palermo – Singles

The 1999 Torneo Internazionali Femminili di Palermo singles was the singles event of the twelfth edition of the second most prestigious women's tennis tournament held in Italy. Patty Schnyder was the defending champion, but she did not compete this year.

Qualifier and World No. 196 Anastasia Myskina won in the final, 3–6, 7–6(7–3), 6–2, against Ángeles Montolio, to win her first WTA title.

Seeds
• # 🇫🇷 Sarah Pitkowski (quarterfinals)

• # 🇪🇸 Magüi Serna (first round)

• # 🇪🇸 Virginia Ruano Pascual (first round)

• # Emmanuelle Gagliardi (first round)

• # Katarina Srebotnik (semifinals)

• # 🇩🇪 Elena Wagner (first round)

• # 🇧🇪 Laurence Courtois (quarterfinals)

• # Miriam Oremans (first round)

Seeds
• # Miroslava Vavrinec (qualifier)

• # 🇺🇸 Samantha Reeves (qualifying competition, lucky loser)

• # 🇷🇴 Andreea Vanc (second round)

• # Larissa Schaerer (second round)

• # 🇧🇪 Patty Van Acker (qualifying competition, lucky loser)

• # 🇫🇷 Lea Ghirardi (first round)

• # 🇭🇺 Katalin Marosi (first round)

• # 🇮🇹 Germana Di Natale (first round)

Qualifiers
• # Miroslava Vavrinec

• # 🇮🇹 Alice Canepa

• # 🇷🇺 Anastasia Myskina

• # 🇮🇹 Giulia Casoni

Lucky losers
• # 🇺🇸 Samantha Reeves

• # 🇧🇪 Patty Van Acker