1 Main Street

1 Main Street is a historic building in Yarmouth, Maine. It is located in the town's Lower Falls neighborhood, beside the First Falls and near Main Street's intersection with East Main Street. It stands across the Royal River from Grist Mill Park, which was the site of several mills in the 17th century.

In the 18th century, it was the site of James Craig's sawmill. In 1911, Yarmouth Manufacturing Company's electric power plant was built at the location. Later businesses on this side included a fishing, hunting and camping equipment store and Industrial Wood Products. In the present-day building are F. M. Beck, C. A. White & Associates and Maine Environmental Laboratory.