2,5-Dimethoxy-p-cymene

2,5-Dimethoxy-p-cymene, or thymohydroquinone dimethyl ether, is a phytochemical found in the essential oils of plants within the family Asteraceae. These essential oils, which contain the compound as a major component of the oil, have antifungal, antibacterial, and insecticidal properties.

Natural occurrence
2,5-Dimethoxy-p-cymene occurs in a variety of different plants' essential oils. Examples include:


 * Ayapana triplinervis (92.8%)
 * Apium leptophyllum (50.7 to 80.24%)
 * Cyathocline purpurea (57.4%)
 * Arnica montana (32.6%)
 * Laggera crispata (32.2%)
 * Blumea perrottetiana (30.0%)
 * Eupatorium capillifolium (20.8%)
 * Sphaeranthus indicus (18.2%)
 * Limbarda crithmoides (16.4)
 * Bubonium imbricatum (16.2%)

Chemical synthesis
2,5-Dimethoxy-p-cymene can be synthesized from carvacrol by aromatic halogenation followed by nucleophilic substitution with sodium methoxide and Williamson ether synthesis using methyl iodide.