2-alkenal reductase

In enzymology, a 2-alkenal reductase is an enzyme that catalyzes the chemical reaction


 * n-alkanal + NAD(P)+ $$\rightleftharpoons$$ alk-2-enal + NAD(P)H + H+

The 3 substrates of this enzyme are n-alkanal, NAD+, and NADP+, whereas its 4 products are alk-2-enal, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is n-alkanal:NAD(P)+ 2-oxidoreductase. Other names in common use include NAD(P)H-dependent alkenal/one oxidoreductase, and NADPH:2-alkenal alpha,beta-hydrogenase.

Structural studies
As of late 2007, three structures have been solved for this class of enzymes, with PDB accession codes, , and.