2000–01 Midland Football Combination

The 2000–01 Midland Football Combination season was the 64th in the history of Midland Football Combination, a football competition in England.

Premier Division
The Premier Division featured 18 clubs which competed in the division last season, along with three new clubs:
 * Clubs promoted from Division One:
 * Brookvale Athletic, who also changed name to Sutton Town
 * Romulus
 * Plus:
 * Pershore Town, relegated from the Midland Football Alliance

Also:
 * Marconi changed name to Coventry Marconi
 * Blackheath Electrodrives changed name to Blackheath Invensys