2000 Campionati Internazionali di Sicilia – Singles

Arnaud Di Pasquale was the defending champion, but did not compete this year.

Olivier Rochus won the title by defeating Diego Nargiso 7–6(16–14), 6–1 in the final.

Seeds
• # 🇦🇷 Mariano Puerta (second round, retired)

• # 🇪🇸 Fernando Vicente (first round)

• # (n/a)

• # 🇪🇸 Francisco Clavet (second round)

• # 🇦🇹 Stefan Koubek (first round)

• # 🇪🇸 Alberto Martín (quarterfinals)

• # 🇪🇸 Albert Portas (second round)

• # 🇪🇸 Álex Calatrava (second round)