2000 Conference USA men's basketball tournament

The 2000 Conference USA men's basketball tournament was held March 8–11 at The Pyramid in Memphis, Tennessee.

Saint Louis upset DePaul in the championship game, 56–49, to clinch their first Conference USA men's tournament championship.

The Billikens, in turn, received an automatic bid to the 2000 NCAA tournament. They were joined in the tournament by fellow C-USA members Cincinnati, DePaul, and Louisville, who all earned at-large bids.

Format
There were no new changes to the tournament format. The top four teams were given byes into the quarterfinal round while the remaining eight teams were placed into the first round. All seeds were determined by overall regular season conference records.