2000 Family Circle Cup – Singles

Mary Pierce defeated Arantxa Sánchez Vicario in the final, 6–1, 6–0 to win the singles tennis title at the 2000 Family Circle Cup. She lost just 12 games during the tournament, surpassing Chris Evert's record of 15 games conceded during her title win in 1985. It was the 1st title of the year for Pierce and the 14th of her career.

Martina Hingis was the reigning champion, but did not compete this year.

Seeds
The first eight seeds received a bye into the second round. • # 🇫🇷 Mary Pierce (champion)

• # 🇪🇸 Conchita Martínez (semifinals)

• # 🇺🇸 Monica Seles (semifinals)

• # 🇪🇸 Arantxa Sánchez Vicario (final)

• # 🇦🇹 Barbara Schett (second round)

• # 🇷🇺 Anna Kournikova (third round)

• # 🇺🇸 Amy Frazier (third round)

• # Amanda Coetzer (quarterfinals)

• # 🇷🇺 Elena Likhovtseva (third round)

• # Silvija Talaja (first round)

• # 🇷🇴 Ruxandra Dragomir (quarterfinals)

• # 🇺🇸 Lisa Raymond (third round)

• # Patty Schnyder (third round)

• # 🇺🇸 Corina Morariu (second round)

• # 🇷🇺 Elena Dementieva (third round)

• # 🇱🇺 Anne Kremer (first round)