2000 Grand Prix de Tennis de Lyon – Singles

Nicolás Lapentti was the defending champion, but did not participate this year.

Arnaud Clément won the tournament, beating Patrick Rafter 7–6(7–2), 7–6(7–5) in the final.

Seeds
• # 🇧🇷 Gustavo Kuerten (quarterfinals)

• # 🇺🇸 Andre Agassi (semifinals, retired)

• # 🇸🇪 Thomas Enqvist (quarterfinals)

• # 🇪🇸 Àlex Corretja (first round)

• # 🇦🇷 Franco Squillari (second round)

• # 🇦🇺 Mark Philippoussis (second round)

• # 🇫🇷 Cédric Pioline (first round)

• # 🇦🇺 Patrick Rafter (final)