2000 Mississippi Valley State Delta Devils football team

The 2000 Mississippi Valley State Delta Devils football team represented Mississippi Valley State University as a member of the Southwestern Athletic Conference (SWAC) during the 2000 NCAA Division I-AA football season. Led by second-year head coach LaTraia Jones, the Delta Devils compiled an overall record of 3–8, with a conference record of 2–5, and finished fourth in the SWAC East Division.