2000 Southwest Missouri State Bears football team

The 2000 Southwest Missouri State Bears football team represented Southwest Missouri State University (now known as Missouri State University) as a member of the Gateway Football Conference (GFC) during the 2000 NCAA Division I-AA football season. Led by second-year head coach Randy Ball, the Bears compiled an overall record of 5–6, with a mark of 2–4 in conference play, and finished tied for fifth in the GFC.