2000 Sybase Open – Singles

Mark Philippoussis was the defending champion and successfully defended his title, by defeating Mikael Tillström 7–5, 4–6, 6–3 in the final.

Seeds
• # (n/a)

• # 🇦🇺 Mark Philippoussis (champion)

• # (n/a)

• # 🇺🇸 Michael Chang (quarterfinals)

• # 🇺🇸 Jim Courier (semifinals)

• # 🇦🇷 Franco Squillari (first round)

• # Wayne Ferreira (semifinals)

• # 🇺🇸 Jan-Michael Gambill (first round)