2000 U.S. Men's Clay Court Championships – Singles

Magnus Norman was the defending champion, but did not compete this year.

Qualifier Fernando González won the first title of his career by defeating his compatriot Nicolás Massú 6–2, 6–3 in the final.

Seeds
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.


 * 1) 🇦🇺 Andrew Ilie (first round)
 * 2) 🇺🇸 Jan-Michael Gambill (first round)
 * 3) 🇮🇹 Gianluca Pozzi (quarterfinals)
 * 4) 🇦🇺 Jason Stoltenberg (second round)
 * 5) 🇺🇸 Paul Goldstein (second round)
 * 6)  Nicolás Massú (final)
 * 7) 🇧🇷 André Sá (first round)
 * 8) 🇺🇸 Justin Gimelstob (first round)

Qualifying seeds
• # 🇦🇺 James Sekulov (first round)

• # 🇫🇮 Tuomas Ketola (first round)

• # 🇧🇪 Xavier Malisse (qualified)

• # 🇦🇷 Mariano Hood (qualifying competition)

• # 🇬🇧 Arvind Parmar (first round)

• # 🇦🇺 Todd Woodbridge (first round)

• # 🇵🇪 Luis Horna (second round, retired)

• # 🇬🇧 Barry Cowan (first round)

Qualifiers
• # Ramón Delgado

• # Fernando González

• # 🇧🇪 Xavier Malisse

• # Răzvan Sabău