2001 Acura Classic – Singles

Venus Williams was the defending champion and successfully defended her title, by defeating Monica Seles 6–2, 6–3 in the final.

Seeds
All seeds received a bye into the second round. • # Martina Hingis (semifinals)

• # 🇺🇸 Venus Williams (champion)

• # 🇺🇸 Jennifer Capriati (quarterfinals)

• # 🇺🇸 Lindsay Davenport (semifinals)

• # 🇧🇪 Kim Clijsters (second round)

• # 🇫🇷 Nathalie Tauziat (quarterfinals)

• # 🇺🇸 Monica Seles (final)

• # 🇷🇺 Elena Dementieva (third round)

• # 🇷🇺 Anna Kournikova (second round)

• # 🇧🇬 Magdalena Maleeva (third round)

• # 🇺🇸 Meghann Shaughnessy (third round)

• # 🇫🇷 Sandrine Testud (quarterfinals)

• # 🇪🇸 Arantxa Sánchez Vicario (second round)

• # 🇺🇸 Amy Frazier (second round)

• # Jelena Dokic (third round)

• # 🇦🇹 Barbara Schett (third round)