2001 Brasil Open – Women's singles

Rita Kuti-Kis was the defending champion but chose to compete at Waikoloa during the same week, losing in the first round to Adrienn Hegedűs.

Monica Seles won the title by defeating Jelena Dokic 6–3, 6–3 in the final.

Seeds
The first four seeds received a bye to the second round. • # 🇺🇸 Monica Seles (champion)

• # Jelena Dokic (final)

• # Amanda Coetzer (quarterfinals)

• # 🇮🇹 Silvia Farina Elia (quarterfinals)

• # 🇸🇰 Henrieta Nagyová (semifinals)

• # 🇪🇸 Cristina Torrens Valero (second round)

• # Patty Schnyder (first round)

• # 🇷🇺 Tatiana Panova (quarterfinals)