2001 Campionati Internazionali di Sicilia – Singles

Olivier Rochus was the defending champion but did not compete that year.

Félix Mantilla won in the final 7–6(7–2), 6–4 against David Nalbandian.

Seeds
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.


 * 1) 🇪🇸 Àlex Corretja (second round)
 * 2) 🇪🇸 Carlos Moyá (first round)
 * 3) 🇪🇸 Albert Portas (semifinals)
 * 4) 🇪🇸 Tommy Robredo (semifinals)
 * 5) 🇪🇸 Albert Costa (quarterfinals)
 * 6) 🇸🇪 Andreas Vinciguerra (second round)
 * 7) 🇦🇷 Franco Squillari (second round)
 * 8) 🇪🇸 Galo Blanco (second round)