2001 Eastern Illinois Panthers football team

The 2001 Eastern Illinois Panthers represented Eastern Illinois University as a member of the Ohio Valley Conference (OVC) during the 2001 NCAA Division I-AA football season. Led by 15th-year head coach Bob Spoo, the Panthers compiled an overall record of 9–2, winning the OVC title with a conference mark of 6–1. Eastern Illinois was invited to the NCAA Division I-AA Football Championship playoffs, where they lost in the first round to Northern Iowa. The Bobcats were ranked ninth in the final Sports Network poll.