2001 Grand Prix de Tennis de Lyon – Singles

Arnaud Clément was the defending champion but lost in the second round to Xavier Malisse.

Ivan Ljubičić won in the final 6–3, 6–2 against Younes El Aynaoui.

Seeds
• # 🇧🇷 Gustavo Kuerten (first round)

• # 🇪🇸 Juan Carlos Ferrero (quarterfinals)

• # 🇷🇺 Marat Safin (semifinals)

• # 🇫🇷 Sébastien Grosjean (second round)

• # 🇫🇷 Arnaud Clément (second round)

• # 🇸🇪 Thomas Johansson (withdrew)

• # 🇪🇸 Albert Portas (first round)

• # 🇪🇨 Nicolás Lapentti (second round)

• # Sjeng Schalken (first round)