2001 Mississippi Valley State Delta Devils football team

The 2001 Mississippi Valley State Delta Devils football team represented Mississippi Valley State University as a member of the Southwestern Athletic Conference (SWAC) during the 2001 NCAA Division I-AA football season. Led by third-year head coach LaTraia Jones, the Delta Devils compiled an overall record of 1–10, with a conference record of 1–6, and finished fifth in the SWAC East Division.