2001 Sybase Open – Singles

Mark Philippoussis was the defending champion but lost in the second round to Juan Balcells.

Greg Rusedski won in the final 6–3, 6–4 against Andre Agassi.

Seeds
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.


 * 1) 🇺🇸 Andre Agassi (final)
 * 2) 🇦🇺 Lleyton Hewitt (quarterfinals)
 * 3) 🇦🇺 Mark Philippoussis (second round)
 * 4) 🇩🇪 Tommy Haas (quarterfinals)
 * 5)  Sjeng Schalken (first round)
 * 6) 🇺🇸 Jan-Michael Gambill (semifinals)
 * 7) n/a
 * 8) 🇬🇧 Greg Rusedski (champion)